And then you have the T. Lost mega satan unlock. Increases the time that status effects stay on enemies. grey, gray, lamp, UNLOCK: Unlock this item by making a Super Bandage Girl, * boss room pool, boss room item, pink, plaster, sticker, item room, treasure room, item room pool, the lost item pool, When used Isaac transforms into pacman, which makes him invincible for 6 seconds and does 40 contact damage to enemies per chomp, Everytime you 'eat' 2 enemies, you regain 1/2 heart of red health, You can't shoot tears while the effect is active, UNLOCK: Unlock this item by visiting 10 arcades, * item room, treasure room, item room pool, gameboy, grey, gray, white, A bag that floats around following Isaac and drops a random coin every 2 rooms, UNLOCK: Unlock this item by beating Isaac with Cain, * secret room pool, item room, treasure room, item room pool, bag, purple, pouch, A familiar which follows Isaac and shoots lasers, similar to the Technology item, Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment), Robo-Baby's lasers deal 3.5 damage per hit, * item room, treasure room, item room pool, robo baby, robot baby, white, grey, gray, silver, red, A familiar which follows Isaac and drops half a red heart every 3 rooms, UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D, * lil chad, little chad, item room, treasure room, item room pool, the lost item pool, red, smile, face, bug, Any pickups are possible from this item, including Bombs, hearts, keys, coins, pills, batteries, tarot cards, runes etc, Doesn't produce microbatteries, only regular sized ones and rarely golden/mega batteries, UNLOCK: Unlock this item by beating each of the Seven Sins once, Item Pool: Item Room, Library, Devil Room, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book, grey, gray, black, A blue cross that follows Isaac and drops a soul heart every 7-8 rooms, REPENTANCE - The Relic now generates soul hearts less frequently, UNLOCK: Unlock this item by beating the Isaac boss with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Cursed gives a card that buys everything in a shop for free (or devil room) Waka Waka and the Host unlock some great items (scythe tears, and added laser to your tears without harming normal tears) Family Man unlocks epic fetus, which is way overpowered. REPENTANCE - This item was completely reworked for Repentance and no longer forces a random dice use each time. In The Binding of Isaac: Repentance, there are two routes to unlock Jacob and Esau. Using it with less than 5 coins does nothing, UNLOCK: Unlock this item by collecting 99 coins then spending all of them in the same run, Item Pool: Item Room, Greed Mode Item Room, Upon use, grants use of Brimstone for the current room, If used twice in the same room, the brimstone laser becomes massive and deals +1.8 more damage, Using it more than twice in the same room will give a damage increase each time. PAC1F1ST. The more items in a pool, the more likely that pool will be picked, A familiar grey spider that wanders around and allows you to see your tear damage and the health bars of all enemies, The spider will inflict a random status effect on any enemies it comes into contact with (e.g. in The Chest as Apollyon, Upon entering a room with enemies, spawns a Black Locust that deals quadruple Isaac's damage, applied as two hits of double damage, UNLOCK: Unlock this trinket by defeating The Lamb as Apollyon, At the start of each new hostile room you spawn 2-5 white attack flies, which will target a nearby enemy and deal double your tear damage to it, UNLOCK: Unlock this trinket by defeating Boss Rush as Apollyon, When killing an enemy, you have a very small chance to gain the ability to fly for the rest of the room, UNLOCK: Unlock this trinket by defeating Greedier Mode with Azazel, Stem Cell heals Isaac's red heart containers to 50% each floor, If Isaac already has 50% health or more, it heals half of a heart instead, UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson, Fully recharges your active item at the start of each boss fight, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Zaratus, Gives you the Holy Mantle shield effect at the start of every new floor, which protects you from the next hit of damage you take, Does not recharge until the start of the next floor, Stacks with the effects from Holy Mantle and Blanket, but it does not stack with Holy Card, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ep and Mills, Using your active item while holding this trinket will drop it back on a pedestal on the ground, Also after taking damage, you have a very small chance to drop one of your passive items, One-time use active items will be consumed and not dropped, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by MarkusLeben and iguesti, *, yellow, golden, box, block, square, cube, Holding this trinket will cause the Angel mini bosses to drop normal items instead of Key Pieces, Added as part of the Afterbirth+ Booster Pack #2, designed by Edmund McMillen, While held, the last door Isaac went through stays open, allowing him to leave the room even if enemies are in it, This trinket works on boss rooms (except Ultra Greed) and devil rooms containing Krampus, allowing you to exit out mid-fight, UNLOCK: Unlock this trinket by blowing up doors and secret room walls 50 times, *, door, stop, wedge, cheese, wood, brown, hodor, game of thrones, Wylis, After being picked up, a yellow laser chain now flows through Isaac's familiars, Added as part of the Afterbirth+ Booster Pack #4 and based on the Steam Workshop mod created by Strawrat and Aczom, While held, spawns +1 friendly blue fly every time you pick up a coin, Added as part of the Afterbirth+ Booster Pack #5. The only way to remove broken hearts is by donating to a Confessional Machine, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Jacob & Esau, Holding the fire button charges up a light beam attack similar to Brimstone, The light beam deals damage equal to your current tear damage per tick to any enemies touching it, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Bethany, When picked up, this item gives you a stat increase, based on which is currently the lowest. If you get hit while Cursed eye is a solid black colour you are guaranteed to be teleported to another random room on the floor. Items for 15c, hearts for 3c, sacks for 7c, UNLOCK: Unlock this card by defeating challenge #44 (Red Redemption), Activates a random effect from a Dice room, See the dice icon above for each possible effect, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Cain, All enemies in the current room are slowed and take double damage, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Samson, You turn into the Keeper, gaining triple shot, -0.1 Speed Down for 30 seconds, Enemies drop random coins while this effect is active, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Keeper, Activates the Book of the Dead effect, spawning a bone orbital or charmed Bony for each enemy killed in the current room, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Forgotten, When used, this card activates 5 random pill effects one after the other, UNLOCK: Unlock this card by defeating challenge #45 (DELETE THIS), Activates The Bible effect (granting flight) and gives a Seraphim familiar for 30 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Azazel, Spawns 6 clusters of rocks and objects that normally appear on this floor, Rocks have a pretty good chance to become tinted rocks, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Apollyon, Removes your oldest item and spawns 2 pedestal items from the current room's pool, Can remove either passive or active items, Doesn't remove your character's starting items, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Isaac, Teleports you to the ultra secret room on the floor, The ultra secret room is a red room containing an item from the angel room item pool. Subscribe. * item room, treasure room, item room pool, white, purple, Gives Isaac the ability to fly and spectral tears, * devil pool, devil room pool, devil deal, red, crescent, moon, drop, black, Creates 5 beams of light from the sky that deal damage equal to your tear damage + 20 to any enemies which come into contact with them, The beams have a high chance to spawn on top of enemies where possible, * item room, treasure room, item room pool, feather, white, arrow, Upon death, you respawn in the previous room as Blue Baby with three Soul hearts, This is a one time use item and all new heart containers will be soul hearts, Can be used to unlock some of Blue Baby's secrets before having the character available, * item room, treasure room, item room pool, black, grey, gray, extra life, egypt, grey, gray, Upon taking damage, you have a 20% chance to gain an invulnerability shield for 7 seconds, The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time, UNLOCK: Unlock this item by beating the Chest with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, 15 Of The Best Items In The Binding Of Isaac 15 Mutant Spider. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. ), REPENTANCE - The hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, red, wire, white, eye, Isaac can now charge shots for more damage by holding down the fire button, At full charge, your tears do 4 times more damage, Tears fired at the minimum possible charge do roughly 1/3 of your normal damage, You can spam the fire button to rapid fire, however the overall damage per second will be low, * item room, treasure room, item room pool, brown, glass, beaker, white, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, FRA1DN0T. Larry Jr.) it will split them into 2 smaller enemies with half the number of sections they used to have, If the enemy normally has a mechanic that splits it (e.g. e.g. With just a bit of prior knowledge, finding USRs becomes pretty reliable, meaning any run that can gain access to Red Rooms will quickly ball out of control. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost', If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway, UNLOCK: Unlock this item by beating the Chest with Eden, 80% of heart drops are replaced with keys, Hearts turn into black hearts where possible. Kills poop bosses when used - Dingle, Dangle and Brownie, * item room, treasure room, item room pool, silver spoon handle, grey, gray, white, toilet. Having trouble unlocking unlocks and achievement while having just cosmetic mods active. If picked up by Cain, it shoots blood tears and the damage becomes increased to 5 (instead of the usual 3.5), UNLOCK: Unlock this item by beating the Dark Room with Cain, * golden chest pool, gold chest pool, item room, treasure room, item room pool, follower, everyone knows it's abel, brown, grey, gray, dead, head, grey, green cain and abel cain & abel, UNLOCK: Unlock this item by beating Challenge #14 (It's in the Cards), * item room, treasure room, item room pool, bloody, silver, grey, gray, sharp, Item Pool: Item Room, Secret Room, Bomb Beggar, * secret room pool, item room, treasure room, item room pool, smile, face, grinning, doitfgt, REPENTANCE - The list of possible tear effects was updated in Repentance, to include all missing and new ones, * item room, treasure room, item room pool, pink note, money, cash, three dollar bill, Also works for opening Spiked Chests and Mimic Chests without taking damage, When used, this item restarts the game and places you back on the first floor with all your currently collected items, similar to doing a Victory Lap, Allows angel rooms to be found in the new run if a devil deal was taken in the first run, In Greed Mode and while playing as Tainted Keeper, this item costs 99 coins instead of 15. blue, glow, 69, Isaac increases in size, gets a lion's mane and now has the ability to crush rocks by walking over them, Crushed rocks and poop can fill holes if you walk in their direction, Allows you to crush Red Poops and sometimes not take damage. Gives a one-time use of the D6 and D20 effects at the same time, When used will cause two of Mom's Hand to come down and grab a random enemy, Grants the Holy Mantle effect for, which will negate your next hit of damage, Tainted Lost starts with this card, and while playing as this character all cards and runes have a 10% chance to turn into a Holy Card, UNLOCK: Unlock this item by defeating Delirium in The Void floor with The Lost. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. the lost item pool, purple, cross, Item Pool: Curse Room, Devil Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, red, 666, Item Pool: Devil Room, Curse Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract, The stationary head is now affected by Isaac's stats and attack modifiers, and the body will spew a controllable fountain of blood shots. For Items it increases by 2 coins * the number of purchases. After a few seconds, he will quickly attack each target, chaining higher damage for each enemy it hits, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Judas, When used this will cause 8 poison farts that leave a brown creep behind, and then drop 7 Butt Bombs very quickly, Standing in the creep gives you +1 Damage Up and +1.35 Tears Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Blue Baby, For the current room, 14 Dead Birds fly in from off the screen and attack all enemies, dealing low but frequent damage, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eve, Isaac gains the Berserk! However, some are a little more hidden, including what might be Repentance's most interesting series of unlocks. Pressing 3 yellow buttons on the floor causes the minecart to be rideable. Isaac doesn't take damage from this effect, UNLOCK: Unlock this item by defeating Delirium as Tainted Lost, Spawns a familiar that's attached via an Umbilical Cord, but will move and shoot in the same direction Isaac is shooting, When activated you first need to throw the familiar, which deals x3 your tear damage to any enemies it touches, Gello's tears deal x0.75 your tear damage (x1.0 if Lilith), Can be used multiple times per room to spawn more familiars, however they only last for the current room, UNLOCK: Unlock this item by defeating Delirium as Tainted Lilith, When used, this item allows you to throw your head where it will sit as a stationary sentry firing bullets until you walk over and pick it up again, Throwing Isaac's head deals 24 damage to anything it hits while being thrown, Your hitbox remains with the body.
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