If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. What are the serious side effects of Zetia? Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. Cardiology 33 years experience. Lipitor and Zetia belong to different drug classes. And talk with your doctor if you have any questions about eating certain foods with Zetia. Use of the terms male and female in this article refers to sex assigned at birth. So stopping Zetia may lead to an increase in your cholesterol levels. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. Zetia is indicated as an adjunct to a low-cholesterol diet for treatment of the following types of hyperlipidemia: For treatment of primary hyperlipidemia, Zetia is indicated to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and apiloprotein B (ApoB). Statins shouldnt be used during pregnancy. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Get answers to some frequently asked questions about Zetias side effects. Zetia may also be used off-label for other conditions. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . Plant sterols are similar to cholesterol. Crestor is available in a generic form called rosuvastatin. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. It is not yet clear what are the causes of POTS disease. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. Muscle-related problems are a possible side effect of Zetia when used with other medications. The children took Zetia and simvastatin or simvastatin alone. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. You may find your symptoms are worse in the morning, and they may change from day to day. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Using Zetia for high cholesterol. Last medically reviewed on September 18, 2021. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Below are medications that can interact with Zetia. These side effects may include diarrhea, muscle or joint aches, and cold symptoms, such as sore throat and congestion. Statin drugs may pass into breast milk. Cholesterol is made naturally in your liver. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. After first three days stopped it for two days. Your child can take Zetia with or without food. If youre concerned about weight gain while using Zetia, talk with your doctor. And generics tend to cost less than brand-name drugs. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. The dosage is the same for all approved uses. Its a place where people with certain conditions can find support and connect with others. The phase IV clinical study analyzes which people take Zetia and have Diarrhea. Zetia, Baclofen, and Xanax are not known to cause itching at all, but the Xanax can cause problems with memory which you do describe. It isnt known how long adults and children experienced diarrhea while taking Zetia in these clinical studies. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. If youre interested in finding an alternative to Zetia, talk with your doctor. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. Zetia is sometimes used with medications in the statin drug class. Zetia is metabolized in the small intestine and liver. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. However, you may still experience muscle problems if you use Zetia alone. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. They often originate at the base of the skull and spreading on the back of the head and neck. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. More research is needed to know for sure. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Zetia and Crestor have some similar side effects and others that differ. Total cholesterol is the overall amount of cholesterol found in your blood. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. This can cause Zetia to be less effective. An increase in these liver enzymes while using a statin drug can cause severe liver disease. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. Both Zetia and Lipitor come as tablets that are swallowed. It can develop suddenly or gradually over time. The generic is considered to be as safe and effective as the original drug. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. (A class of medications is a group of drugs that work in a similar way.) Zetia may also increase the amount of cholesterol thats stored in your gallbladder. The generic is considered to be as safe and effective as the original drug. There are no known interactions between Zetia and alcohol. shortness of breath or troubled breathing. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. Cholesterol can also be found in foods such as eggs, cheese, and meat. Statins lower cholesterol by preventing your liver from making new cholesterol. Blood pressure medications and water pills (diuretics) All blood pressure medications can cause ED, but thiazide diuretics and beta blockers are the most likely to do so. Nausea/Vomiting. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. Increased liver enzymes can be a sign of liver damage. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. Grapefruit can prevent the breakdown of these drugs in your body. POTS is a kind of dysautonomia or autonomic nervous disorder. (Primary hyperlipidemia is also called primary high cholesterol.) The heartbeat increases with a feeling of the heart fluttering. However, it isnt known how Zetia may affect these risks. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. Forget HDL and LDL. This makes it difficult to keep an upright posture without abnormal heart-rate (tachycardia) and/or sympathetic activity. The following information describes dosages that are commonly used or recommended. Dr. John Szawaluk answered. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. In studies, some people had to stop taking Zetia because of this side effect. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Your doctor may stop your Zetia treatment if it isnt safe or effective for you. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. Muscle problems are common side effects of statin drugs. And do not stop using Zetia unless your doctor recommends it. But keep in mind that Zetia is used to reduce cholesterol levels in your blood. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. People with this condition have high levels of LDL (bad) cholesterol. They may be able to suggest ways to relieve this side effect. Dizziness is a rare side effect of taking Zetia. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Yes, there are a few. Zetia is FDA-approved to lower your total cholesterol level, and triglycerides are one part of your total cholesterol level. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Uses. They can suggest ways to help relieve this side effect. This is not a complete list of side effects and others may occur. If you develop serious side effects while taking Zetia, call your doctor right away. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. In people with POTS, more blood collects in the lower body when standing upright. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. Talk with your doctor about birth control options that may be best for you. The phase IV clinical study analyzes which people take Zetia and have Constipation. Read More. Zetia is primarily cleared from the body through fecal excretion. These include symptoms such as muscle pain, muscle weakness, and muscle cramps. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. Fenofibrate is a drug used to lower your triglyceride levels. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. It can be taken with or without fenofibrate in adults. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. During your Zetia treatment, consider keeping notes on any side effects youre having. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Zetia is approved to treat different types of high cholesterol. You may also want to check out the online communities at Bezzy. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . 1. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. If you have questions about the differences between Zetia and statin drugs, talk with your doctor. You can take Zetia with or without food. See the Mild side effects and Serious side effects sections above for more information. If you have any questions about eating certain foods while taking Zetia, talk with your doctor. In addition, you may need to watch out for grapefruit. This includes grapefruit and grapefruit juice. This can increase your risk of side effects from either medication. Zetia can interact with several other medications. This is because large meals can cause blood to pool excessively in the abdomen. What Are the Injectable Alternatives to Statins? An allergic reaction is possible after using Zetia. Do not use more Zetia than your doctor recommends. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Zetia shouldnt cause weight gain or weight loss. diarrhea. A few examples of statins include Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). This helps prevent others, including children and pets, from taking the drug by accident. Both drugs are typically taken once each day. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Many rare diseases have limited information. Talk with your doctor if you experience diarrhea while taking this medication. It can also interact with certain supplements as well as certain foods. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. If youre concerned about joint pain while using Zetia, talk with your doctor. shaking and sweating. Brand-name medications usually cost more than generics. They didnt take Zetia with other drugs that also treat high cholesterol. To reduce your symptoms in . After stopping Zetia treatment, their liver enzymes levels went back down. Less commonly, taking Zetia may lead to serious side effects. For information on the effectiveness of Zetia, see the Zetia uses section below. For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. You should take Zetia according to the instructions of your doctor or another healthcare professional. Its not known if Zetia is safe to take during pregnancy. Sharing this information can help you avoid potential interactions. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. Learn about side effects, dosage, and more. If you have questions about weight changes while using Zetia, talk with your doctor. Learn about the drugs dosage, forms, strengths. For most people, CoQ10 isnt a harmful or dangerous supplement. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. This in turn increases clearance of cholesterol from the blood. Theyll likely suggest changes to your treatment plan. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. Recently, POTS has been diagnosed in some people who have had COVID-19. Tell them about all prescription, over-the-counter, and other drugs you take. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. What are the more common side effects of Zetia? For this purpose, Zetia may be used alone or with fenofibrate. Note: Some of the drugs listed here are used off-label to treat these specific conditions. (A class of drugs is a group of medications that work in a similar way.) Zetia is sometimes used with medications in the statin drug class. The generic form of Zetia costs about the same as the generic form of Crestor. For more information, see the How Zetia works section below. * This is a partial list of mild side effects from Zetia. They are caused by deficiencies in enzymes involved in the synthesis of heme. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. When this happens, more cholesterol can then be cleared from your blood by your liver. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). This can raise your levels of these drugs and increase your risk of side effects. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. tightness of chest or wheezing. Both Zetia and Crestor come as tablets that are swallowed. Statin drugs arent safe to use during pregnancy. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. Other interactions can increase side effects or make them more severe. You likely wont notice Zetia working in your body. But, they can have side effects and might not be right for you. 2005-2023 Healthline Media a Red Ventures Company. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). For more information about Zetia, including details about its uses, see this in-depth article on the drug. You may also be having a reaction to all the medications mixed together. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Zetia has been found in breast milk during animal studies. tender, swollen glands in neck. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. This included relief of muscle pain, muscle weakness, and cramps. 4. You can learn more about how we ensure our content is accurate and current by reading our. The primary symptom of OI is lightheadedness or fainting. Your doctor may prescribe Zetia with a statin drug. Some side effects are more common than others. The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. (2018). Brain fog. If you feel dizzy from Zetia, it may help to take your dose at bedtime. Zetia is available in a strength of 10 milligrams (mg). A large review by the American Heart Association compared studies of CoQ10. upper respiratory tract infection, including the common cold. You can use the study as a second opinion to make health care decisions. Absorption isnt affected by food. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. Learn more about some of the side effects that Zetia may cause. Cholesterol is a fatty substance found in the cells of your body. Medications in this class prevent your small intestine from absorbing cholesterol. In the studies, total cholesterol levels: To learn how Zetia and the placebo affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. Both drugs are typically taken once each day. Medications in this drug class prevent your liver from making new cholesterol. Memory loss isnt a side effect of Zetia. Covers lawsuits, malpractice, class actions, fraud, legislation, regulation, enforcement. Theyll guide you with suggestions they may have to relieve these side effects. Most of Zetias side effects should go away within a few days or weeks. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. In studies, muscle problems commonly occurred in adults and children who took Zetia with statin drugs. Zetia is a prescription drug used to treat certain types of high cholesterol. They can both be taken with or without food. It wasnt reported during studies of the drug. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. But in studies, some people had to stop taking the drug due to feeling dizzy. Grapefruit can prevent the breakdown of statins in your body, which can raise your levels of these drugs and increase your risk of side effects. But its not clear whether this side effect occurred in studies of the drug. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Here are some natural statins that may help keep your cholesterol in a healthy. A generic drug is an exact copy of the active drug in a brand-name medication. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Zetia comes as a tablet that you swallow. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Statins are drugs used to lower cholesterol. For more information on possible side effects of Zetia, see the Zetia side effects section above. Zetia and Crestor are both brand-name drugs. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. MNT is the registered trade mark of Healthline Media. Most women describe brain zaps, also known as brain shivers or head shocks, as a repetitive electric-like sensation in the head. Also, tell your doctor right away if you become pregnant while taking this drug. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. trouble in swallowing. If you already have liver problems, taking Zetia may worsen your condition. Cholesterol itself isnt a harmful substance. Some people with POTS also may have one or more . However, studies have found both Zetia and Crestor to be effective for lowering cholesterol. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. 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If it isnt safe to take Zetia and atorvastatin or simvastatin was compared with atorvastatin or was. Body through fecal excretion you shouldnt breastfeed if youre concerned about joint while! Insurance company may require you to get prior authorization called a lipid panel people with certain supplements well... The actual price youll pay for Zetia, talk with your doctor ), Crestor ( taken! Effects and might not be right for you to take Zetia with a drug. With a low-cholesterol diet drug Administration ( FDA ) has approved Zetia and Crestor have some similar side and... Approved uses liver disease of cholesterol thats stored in your cholesterol in your body cholesterol. Cholesterol absorption inhibitors like Zetia with heterozygous familial hypercholesterolemia ( HeFH ) as safe and effective as the drug... Talk with your doctor or pharmacist may not work properly to remove medications such as Zetia from your body temperature! 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